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SCIENTIFIC SCORE
Questionable
Based on 1 Researches
5
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
5
Folate may reduce antibiotic side effects
Early and late neutropenia in children treated with cotrimoxazole (trimethoprim-sulfamethoxazole).
Study highlights folate's role
We explored the effectiveness of folate treatment in children with ear infections by evaluating hematologic abnormalities during antibiotic therapy. In a study involving 120 children with otitis media, we divided the participants into three groups: one received cotrimoxazole (the combination of trimethoprim and sulfamethoxazole), the second group received cotrimoxazole with folinic acid (a form of folate), and the third group was given amoxicillin.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
Read More
Most Useful Reviews
9.5
Improved immunity
My neurologist prescribed this vitamin B12 supplement to support my nervous system and help with my ear infection-related tinnitus. The small, slightly sweet pills seem to be well absorbed and effective. This autumn, I didn't catch a single cold, and my immunity improved noticeably. It has also enhanced my memory, sleep, and emotional stability, contributing to a better overall state.
Read More
8
Reduced recurrences
I take this for my ears as I've been suffering from an ear infection that keeps returning. I've heard vitamin B12 is beneficial, so I decided to try this product. I can't be certain of the cause, but I used to have recurrences every three months and haven't had one in six months. It may be a relief, but it feels like a lucky charm. The taste is delightful, and I plan to keep taking it.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 1 Researches
5
5
Folate may reduce antibiotic side effects
Early and late neutropenia in children treated with cotrimoxazole (trimethoprim-sulfamethoxazole).
Study highlights folate's role
We explored the effectiveness of folate treatment in children with ear infections by evaluating hematologic abnormalities during antibiotic therapy. In a study involving 120 children with otitis media, we divided the participants into three groups: one received cotrimoxazole (the combination of trimethoprim and sulfamethoxazole), the second group received cotrimoxazole with folinic acid (a form of folate), and the third group was given amoxicillin.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
9.5
Improved immunity
My neurologist prescribed this vitamin B12 supplement to support my nervous system and help with my ear infection-related tinnitus. The small, slightly sweet pills seem to be well absorbed and effective. This autumn, I didn't catch a single cold, and my immunity improved noticeably. It has also enhanced my memory, sleep, and emotional stability, contributing to a better overall state.
Read More
8
Reduced recurrences
I take this for my ears as I've been suffering from an ear infection that keeps returning. I've heard vitamin B12 is beneficial, so I decided to try this product. I can't be certain of the cause, but I used to have recurrences every three months and haven't had one in six months. It may be a relief, but it feels like a lucky charm. The taste is delightful, and I plan to keep taking it.
Read More
